Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences researcher Zheng Yonghui basic immunization innovation led team found a new way HIV envelope protein synthesis inhibition.
Recently, the Chinese Academy of Agricultural Sciences press release, said the hospital Harbin Veterinary Research Institute researcher Zheng Yonghui basic immunization innovation led team found a new way HIV envelope protein synthesis inhibition. The study for the development of AIDS vaccine development and anti-AIDS drugs specified in a new direction. Relevant research results published in the American publication “Journal of Virology.”
According 郑永辉 introduction, the vast majority of animal viruses, including the ability to cause AIDS, Ebola hemorrhagic fever, dengue fever and other serious diseases, viruses, virus particles have a layer in the outer envelope containing glycoprotein. These glycoproteins also called envelope protein, the virus is through the identification of these glycoproteins in infected target cells.
One of the difficulties of AIDS vaccine research is that HIV envelope proteins in mammalian cells is difficult to be highly expressed.
Zheng Yonghui basic immunization innovation team led by studying a strain not to be HIV-infected human T cells revealed that the cell exceeds the amount of expression of a protein called TSPO and cause degradation of viral envelope proteins.
By targeting gene knockout technology, TSPO protein function in-depth study, indicating that the cells down TSPO can increase the synthesis of viral envelope protein, and upregulated TSPO, you inhibit viral envelope protein synthesis, so as to achieve The purpose of the anti-viral infection.
Zheng Yonghui said the results of this study will not only be able to explain the mechanism of HIV envelope protein expression can not efficiently provide clues, but to clarify a novel antiviral mechanism for other research enveloped virus also has reference.