Epicardial progenitor cells in cardiac injury division into fat cells

Chinese Academy of Sciences Shanghai Branch of the Institute of Nutritional Sciences Zhou Bin group recently found in the center of the development process of the outer membrane of cardiac progenitor cells can be transformed into the surrounding fat cells, this process does not occur in the adult heart in the steady state, but is in the MI model re-activated.

Epicardial progenitor cells in cardiac injury division into fat cells

The damaged heart epicardium-derived cells (red) into fat cells (green)

Chinese Academy of Sciences Shanghai Branch of the Institute of Nutritional Sciences Zhou Bin group recently found in the center of the development process of the outer membrane of cardiac progenitor cells can be transformed into the surrounding fat cells, this process does not occur in the adult heart in the steady state, but is in the MI model re-activated. Related Articles published in the September 26, 2014 in “Cell Research” magazine.

Epicardial fat surrounding the heart and coronary vessels is a visceral fat, in order to provide a buffer to protect the role of the heart also increases the risk of coronary heart disease, and coronary atherosclerosis, heart disease, there is a high correlation , and sources of these fats are still unknown.

Located in the heart cells of the outermost layer is a group of epicardial progenitor cells having pluripotency, research to date found to differentiate into fibroblasts, vascular smooth muscle cells or myocardial cells, but its ability to be converted into fat cells was rarely reported. Research to explore the origins of epicardial fat can provide new research directions and ideas for the diagnosis and treatment of coronary heart disease.

In this study, Liu Qiaozhen etc. doctoral researcher under the guidance of Zhou Bin, the use of transgenic mice Wt1-CreERT2; Rosa-RFP, specific markers to track the fate of epicardial cell development. The results showed that embryonic cells labeled epicardial coronary vessels in addition to differentiate into smooth muscle cells than fat cells can also be formed between the atrioventricular heart. However, in the adult epicardial Shique again labeled this phenomenon was not observed, indicating that the ability of the outer membrane into the fat body into the center of the steady state is suppressed. Previous studies have shown that adult cardiac injury, the epicardial cells can re-stimulate the embryonic development of some of the features, differentiate into other cell types. Therefore, further study of the work of the heart damage under changing circumstances epicardial cells into fat cells, the ability, the results surprised to discover that the formation of fatty tissue injury site, while some of the fat cells is derived from the epicardium. The study also found that the cells derived from epicardial and are pluripotent, and under different culture conditions may be induced into adipocytes, chondrocytes and osteoblasts.

The research work is the remainder of the eagle and nutrition researcher, segment wins Chung researcher at Harvard Medical School professor William Pu, Juan Melero-Martin collaboration professor and get the Ministry of Science, NSFC, Chinese Academy of Sciences, Shanghai Science and Technology Commission and other financial support (nutrition that).

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