Researchers hope to recruit 100,000 live in East London, South Africa Pakistanis and Bangladeshis, large long-term study of ethnic communities in poor links between genes and health to participate in an explore.
A new genetic study aims to recruit 100 000 Southeast Asian descent have people of East London. Source: Ibán / Flickr
Researchers hope to recruit 100,000 live in East London, South Africa Pakistanis and Bangladeshis, large long-term study of ethnic communities in poor links between genes and health to participate in an explore. One of the largest research efforts so far this has just started looking for a specific gene deletion, although it is still rare in healthy individuals made.
Many poor immigrants from Pakistan and Bangladesh living in East London. In the high incidence of these communities, heart disease, diabetes and other diseases. East London genes and health research will focus on the two most neglected population genetic studies. “The study of these people as well as to improve public health in East London is a good chance.” One person in charge of the study, from Queen Mary, University of London, said David van Heel. £ 4 million funding Wellcome Trust and the UK Medical Research Council from.
Meanwhile, the researchers hope to collect information Another healthy people, that their bodies of two copies of a gene are mutated in, so that the loss of function of the gene. These rare individuals can clarify “When part of the genetic material is not working what will happen.” Another person in charge of the study, said Richard Trembath. If you lose the gene can somehow fight the disease, then the gene targeted drugs can treat this disease without causing side effects. van Heel said, PCSK9 gene is a case in point. It is because of this gene in Texas, a very healthy female body loss, prompting generate new cholesterol-lowering drugs.
The researchers plan to recruit four years with over 16 years of Bangladesh origin or Pakistani volunteers and whether they healthy or diseased. Participants will donate a saliva sample, and allows scientists to get their health records. van Heel said the Wellcome Trust Sanger Institute have agreed sequenced belongs to the first batch of 25,000 participants in the exome, the work is expected to end in late 2017. Broad Institute in Cambridge, Massachusetts, will help carry out genome analysis.
Some participants may be invited to participate in the next 20 years to the study of human disease and drug response on gene knockout and how specific genes influence. Trembath said that although the volunteers will not receive any direct benefit from the research, but they will have a chance to “impact on the future health of generations.”