Scientists have discovered a nail important clues hidden limb regeneration

Mammals have a remarkable ability to regenerate fingertips, this ability also nails, nerves, bones and even the performance of the regeneration. Broken human fingertip can grow again within two months. Until now, little is known about the people of this capability.

 

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Mammals have a remarkable ability to regenerate fingertips, including the nails, nerves, bones and even the regeneration

According to foreign media reports, the mammal has a remarkable ability to regenerate fingertips, this ability also nails, nerves, bones and even the performance of the regeneration. Broken human fingertip can grow again within two months. Until now, little is known about the people of this capability.

In a recently published in “Nature” journal papers, the New York University Medical Center researchers illustrate this remarkable regenerative capacity of mammals, the use of genetically engineered mice first to demonstrate this capability hidden fingertip regeneration biochemical chain. The study amputees brought hope.

Mayumi Ito professors and their research team has discovered an important clue to fingertip regeneration process – nail matrix (nail matrix) in the number of self-renewing stem cells. Nail matrix is ​​the nail bed (human fingernail or toenail piece of skin covering) as part of the nail bed, nail growth within a rich role in stimulating nerve endings and blood vessels. In addition, the scientists also found that these stem cells rely on what is called a “Wnt signaling network” family of proteins to regenerate fingertips bones. And the hair and tissue proteins also play a key role in the regeneration process.

Dr. Mayumi Ito said: “When we blocked off the fingertips of the Wnt signaling pathway in mice, their nails and bones and did not like the normal regeneration.” Even more interesting is that scientists have discovered that they can manipulate the Wnt signaling pathway beneath the fingertips to stimulate bone and tissue regeneration.These findings suggest that Wnt signaling is very important for the regeneration of the fingertips, but also can help the human limb regeneration therapies invented the way.

The researchers will study the control “Wnt signaling pathway how stem cells interact with nails which affects bone and nail growth,” the molecular mechanism.

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