Edinburgh thymus cells by increasing levels of a protein involved in the regulation of important genes, the first successful in vivo regeneration of an organ. This extension of the field of regenerative medicine.
A research team at the University of Edinburgh, the first successful regeneration of a living organ. The team Reconstruction thymus – a body organ located next to the heart, which can generate important immune cells.
The new study is developed to treat people with compromised immune systems and the impact of genetic diseases thymus development approach paves the way forward.
The team at a very old mice with age reactivate a closed natural growth mechanism, revitalized the thymus. After treatment, a young mice with similar structures found in organ regeneration.
Thymic function has also been restored, the mice began to produce more white blood cells called T cells, which fight infection is an important cell. However, it is not clear whether the mouse immune system has been improved.
The study was conducted by the Research Council of regenerative medicine at Edinburgh University Medical Center researchers completed.
Researchers for a protein produced by the thymus cells – called FOXN1 – an important gene involved in regulating how it started. By increasing the level of FOXN1, the team indicates stem-like cells to rebuild the organ.
“Our findings show that the same pathways for human thymic function can be improved, thus improving the immune system in elderly patients or hypoplasia of the human immune system, however, before human testing this, we need to do more work, to ensure that the process can be strictly controlled, “MRC Medical Center professor of regenerative tissue stem cell biology Clare Blackburn said.
Treatment of hope
With age, the deterioration of the thymus, which is why older people tend to be more susceptible to infection, such as influenza.
The discovery also may lead to thymic hypoplasia as a genetic disease – DiGeorge syndrome patients new hope.
“A major goal of regenerative medicine is to use the body’s own repair mechanisms and means to manipulate the regulation treating diseases of this interesting study shows that organs can be mammalian protein by manipulating the orientation of a single reproduction, the reproduction biology which may Other areas have a broad sense, “the Medical Research Council regenerative medicine dean Dr. Rob Buckle said.
The study was published in the development (Development) magazine.