Totipotent stem cell factor NANOG maintain pluripotency of key proteins

A group of researchers Barcelona genome described control center, a protein plays a crucial role in cell reprogramming. The discovery of this protein is also described in detail the dynamics and their interaction, and pluripotent stem cells and other factors involved in the maintenance of reprogramming.

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A group of researchers Barcelona genome described control center, a protein plays a crucial role in cell reprogramming. The discovery of this protein is also described in detail the dynamics and their interaction, and pluripotent stem cells and other factors involved in the maintenance of reprogramming. The study was published in the “Cell Reports” magazine September 4, 2014 in.

Protein Nanog is a transcription factor, plays a key role in maintaining pluripotent stem cell state. A group of researchers genome control center has been studying the role of this protein in the new study, they reveal a new mechanism for the role of Nanog. Scientists have found that, Nanog involved other agents, and they have dynamics of the protein described in detail. Another protein (β-catenin) In particular, the study also involved in reprogramming cells and they have been able to improve the understanding of the function of Nanog.

Cell renewal is a natural process, continue to occur in our body. To do this, we have to take charge of stem cells produce new cells for death for those supplemented and updated. Stem cells undifferentiated pluripotent stem cells, which have the capacity to become any cell type. These pathways followed by the differentiation of pluripotent stem cells to specialized, neurons can be produced from any type of skin cells.

Scientists want to know, so that stem cells differentiate into any one or maintain pluripotency mechanism. Many studies have attempted to reverse the process, so that differentiated cells reprogrammed to become pluripotent. Know all the members of these processes for understanding how stem cells work is essential, and to promote the advancement of regenerative medicine.

“We know, Nanog in some way involved in the maintenance of stem cell pluripotency, now that we know the mechanism it uses up, and we can better understand how it works,” the authors of the study, one of Lucía Marucci said that she worked at CRG by reprogramming and regeneration laboratory researcher Pia Cosma leadership cells. “Let us study this process found that not only plays a key role in Nanog reprogramming, but also found that another protein kinetics of the process, which is called β-catenin, we now know, β- catenin same as Nanog , constant fluctuations in the cell, not just in the reprogramming process is activated, “This research collaborators, from Elisa Pedone adds the same laboratory.

In order to understand and define the parameters of these two proteins activity, researchers have developed to explain this dynamic mathematical model. This model can be used over time and under different situations, the understanding of these proteins in the cell behavior.

We’re talking about the function and dynamics of stem cell reprogramming a fundamental discovery. More research is ongoing process for future drug tremendous hope. By ICREA Research Professor Pia Cosma leadership lab, this knowledge is to make a decisive contribution. Her group embarked on coordination cell differentiation and reprogramming of the basic mechanisms, specific methods for repair until reprogrammed some tissue damage.

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