Scientists reveal the pathogenesis of hereditary diseases

1957, developmental biologist Conrad Waddington reveals what epigenetic spectrum, commentaries, he proposes how cells move through cell differentiation, and ultimately differentiate into blood, kidney or heart cells.


NEW YORK, September 4 reported that in 1957, developmental biologist Conrad Waddington published a short commentary reveals what epigenetic spectrum, commentaries, he proposed how cells move through cell differentiation, and ultimately differentiate into blood, kidneys or heart cells; but this time, reveal the mechanism of cell differentiation and whether it can return to the most primitive undifferentiated state no one knows, but the answer may answer the question as to solve human health problems such as cancer or genetic diseases will a huge help.

Recently, published in the international journal Genome Research in a research paper, the researchers from the Institute for Biological Informatics of the University of Virginia revealed the biochemical processes of DNA methylation process involved. Xie said the researchers, we used a new technique to study the methylation process of the entire genome of the human body, is designed to track hidden behind cancer or other diseases of important genetic lineages.

Now researchers have begun to discover, on the development of epigenetic and gene expression reveals cells plays an important role in epigenetic changes do not occur at the DNA sequence level, it will change the chromatin, thereby directly change gene expression. DNA methylation, the DNA that is to add a methyl group, one of which is altered gene expression in the way.

DNA methylation patterns can be inherited, but starting from the methylation pattern of the occurrence of cancer research may also help to track cells to a particular tissue, but as of now researchers have not yet succeeded in methylation patterns Genetic been tracking; researcher Xie and his team is the first time the use of hairpin bisulfite sequencing technology on the entire genome for methylation pattern analysis.

For this study, the researchers got a lot of interesting discoveries, such as the precise genetic methylation is highly dependent on specific trans-acting factors binding to the partial sequence; additional researchers developed this new type of hairpin sulfite sequencing technology to conduct in-depth study of DNA methylation provide some technical force. Finally, researchers said this research could perhaps help us to understand the mechanisms of cancer and its relationship with environmental factors for late-stage development of new anti-cancer therapies will provide new clues and data.

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